Why is this research study being done?
The Precision Interventions for Severe and/or Exacerbation-Prone Asthma Network (PrecISE) is a clinical study sponsored by the National Heart, Lung, and Blood Institute (NHLBI). PrecISE’s physician scientists are dedicated to researching better treatments for people living with severe asthma.
PrecISE is a clinical study that uses precision medicine for severe asthma. Precision medicine is an approach to the prevention and treatment of disease that uses information about an individual’s or group’s specific disease process, symptoms, and treatment responses, to identify the medicines and therapies that are most likely to be effective for them.
Researchers from over 30 locations across the US are involved in PrecISE.
Who is eligible for the research study?
The PrecISE study centers will recruit up to 650 adults and 150 teenagers (ages 12 and older). The study participants should meet the criteria for severe asthma that is not well-controlled of with frequent asthma attacks. The participant should also be on a stable treatment. People will be recruited from over 30 sites in the US.
What can I expect as part of the research study?
First, we will determine if a person is eligible for the study. After a person is found to be eligible and they agree to enroll, they will be asked to record their asthma symptoms and undergo tests to understand their type of severe asthma. If enrolled in the study, and qualified for each individual treatment, you could receive up to 5 treatments if 18 years old or older. Each study treatment is 16 weeks. We expect most participants to qualify for and receive 2-3 different treatments, depending on their type of severe asthma and when they enroll.
The study will range from 1 to 3.5 years, depending on the date of enrollment
What do we expect to learn from the study?
PrecISE is different because it is a study to learn what treatments are best for each person, instead of only people with the most common types of asthma. This individual-based care is called Precision Medicine. We will use Precision Medicine to understand which treatments are best for each person.